Membrane-proximal F-actin restricts local membrane protrusions and directs cell migration. © 2020-21 Stanford University. How and when does a student select and convene their dissertation reading or thesis committee? Postdoctoral research training is available to graduates having the Ph.D. or M.D. As a best practice, advising expectations should be periodically discussed and reviewed to ensure mutual understanding. Medical Scholars Research. Prerequisite: biochemistry, chemistry, or bioengineering. Same as: CHEM 289. The HTBC is a Stanford University School of Medicine core facility and was created in 2003 by the Department of Chemical and Systems Biology (formerly Molecular Pharmacology). degree. The Department of Chemical and Systems Biology offers interdisciplinary training to prepare students for independent careers in biomedical science. 3 Units. A Practical Approach to Drug Discover and Development. This includes course work in biology, chemistry, physics, and mathematics. Illustration of key principles that can be generalized to other synthetic and natural biological circuits. A final copy of the report must be submitted to the CSB Student Services Manager. Markus Covert. Students will acquire conceptual and methodological training in a wide range of modern techniques, including "omics" approaches, fluorescence microscopy, genome editing, computational approaches, and quantitative data analysis. Topics include: high throughput assay development, compound screening, lead optimization, protecting intellectual property, toxicology testing, regulatory issues, assessment of clinical need, defining the market, conducting clinical trials, project management, and commercialization issues, including approach to licensing and raising capital. 3 Units. And, how often should the committee meet? The committee should include four faculty members counting the thesis advisor (faculty on the committee do not need to be tenure track). Topics include exploring how feedback mechanisms can be exploited to enable and precisely control tissue regeneration. Course requirements are fulfilled during the first two years of study; the later years of the four- to six-year program are devoted to full-time dissertation research. Students and postdocs are required to give in-depth presentations about their current projects within the academic year. Students are also encouraged to meet with the CSB Advisory Committee members or the Department Chair individually if any issues come up throughout the year. 1-2 Unit. degree after having satisfactorily completed the course and laboratory requirements of the first two years. The main focus of the program is cell signaling, chemical biology, and systems biology. 1 Unit. Research in our laboratories combines state-of-the-art approaches from chemistry, biochemistry, cell biology, genomics, computational modeling, and other disciplines to understand cellular and organismal physiology, predict emergent behaviors, and translate these discoveries into new technologies and therapies. Emeriti: (Professors) Robert H. Dreisbach, Stuart Kim, Richard A. Roth, James P. Whitlock, Director of Graduate Studies: Daniel F. Jarosz, Professors: James K. Chen, Karlene A. Cimprich, James E. Ferrell, Jr., Nathanael Gray (effective Winter Quarter), Tobias Meyer, Daria Mochly-Rosen, Thomas J. Wandless, Joanna K. Wysocka, Assistant Professors: Gheorghe Chistol, Lei Stanley Qi, Courtesy Professors: Philip Beachy, Carolyn Bertozzi, Matthew Bogyo, Justin Du Bois, Beverly S. Mitchell, Paul A. Wender, Courtesy Associate Professors: Markus W. Covert, Michael Z. Lin, Jan M. Skotheim, Aaron F. Straight, Marius Wernig. If a committee meeting is not completed by the end of Summer Quarter, an enrollment hold is placed on the student's account and may delay graduate funding. This course will introduce students to the applications of biotechnology to the discovery and development of novel drugs and therapeutics. Genome stability pathways and their roles in cancer and other human diseases; DNA damage response pathways and DNA replication; the interface between RNA processing and transcription with genome stability. For a statement of University policy on graduate advising, see the "Graduate Advising" section of this bulletin. The department also expects that each student complete for the thesis at least one peer-reviewed, first-author paper that is accepted for publication by the time the oral thesis exam is being scheduled. Same as: BIO 171, BIO 271. CSB 240A. CSB 240B. Palo Alto, CA 94304-5261. Students in the Ph.D. program may apply for an M.S. The discipline of developmental biology draws on biochemistry, cell biology, genetics, molecular biology, and genomics. Learn how to become an affiliate. Chemical and Systems Biology counts all courses taken in academic year 2020-21 with a grade of 'CR' (credit) or 'S' (satisfactory) towards satisfaction of graduate degree requirements that otherwise require a letter grade provided that the instructor affirms that the work was done at a 'B' or better level. chemical and systems biology The Department of Chemical and Systems Biology explores the molecular mechanisms that underlie cellular function and contribute to human disease. Genetic analysis of the key regulatory circuits governing the control of cell division. Mohammad Alnaqib, Undergraduate Student CSB 346. The department emphasizes individualized training at the interface of physical science and biomedical science. Chemistry of Biological Processes. Undergraduate Research. Our faculty members are internationally renowned scientists who foster an innovative and collaborative research environment, and alumni from our home program are leaders in academics, biotech, and science policy. CSB 220. Postdoctoral fellows are an integral part of the Chemical and Systems Biology community, playing active roles in its research and training activities. At least one of the four faculty members has to be a primary faculty in the CSB department, but the composition can be different from that in the qualifying exam and can also change during the student's thesis work as they may need to pursue different directions. After each rotation, students meet with the CSB Advisory Committee to discuss how the rotation went and whether the next rotation is a good match for the student’s educational and professional goals. What topics might be discussed at advising or committee meetings? CSB 250. Course held before corresponding Friday Cutting Lecture Series speaker. Clark W2.1 Over 980 faculty are affiliated with Stanford Bio-X and are eligible to apply for our grants and be notified about fundraising opportunities, collaborations with industries, events, courses and available facilities and instruments. Toggle School of Earth, Energy and Environmental Sciences, Undergraduate Major Unit Requirements and WIMs, Involuntary Leave of Absence and Return Policy, Main Quadrangle • Memorial Court • Oval • White Plaza, Sexual Harassment and Consensual Sexual or Romantic Relationships, Student Non-​Academic Grievance Procedure, Title IX of the Education Amendments of 1972, Visitor Policy • University Statement on Privacy, School of Earth, Energy and Environmental Sciences, Emmett Interdisciplinary Program in Environment and Resources (E-​IPER), Institute for Computational and Mathematical Engineering, Comparative Studies in Race and Ethnicity (CSRE), Division of Literatures, Cultures, and Languages, Russian, East European and Eurasian Studies, Stem Cell Biology and Regenerative Medicine, Master of Science in Chemical and Systems Biology, Doctor of Philosophy in Chemical and Systems Biology. Outside of the laboratory, James enjoys fly fishing for larger model organisms and running half-marathons. The program leading to the Ph.D. degree includes formal and informal study in chemical biology, systems biology, drug discovery, biochemistry, and other areas of relevance to the interests of particular students. Our focus is on building computational models of complex biological processes, and using these models to guide an experimental program. Professor of Bioengineering and, by courtesy, of Chemical and Systems Biology. Prerequisite: 240A. CSB 224. CSB 370. The program leading to the Ph.D. degree includes formal and informal study in chemical biology, systems biology, drug discovery, biochemistry, and other areas of relevance to the interests of particular students. The Department of Chemical and Systems Biology explores the molecular mechanisms that underlie cellular function and contribute to human disease. Enrollment limited to PhD students associated with departmental research groups in genetics or molecular biology. Developmental signaling pathways and their roles in embryonic patterning and oncogenesis; zebrafish models of tissue patterning and regeneration; synthetic chemistry and chemical biology. 3-4 Units. Chemical and Systems Biology Pizza Talks. COVID-19-Related Degree Requirement Changes. Stanford, CA 94305 Required for CSB first and second year students. Stanford chemists are developing new computational tools and theories that allow atomistic dynamic simulations of complex chemical and biological systems that enable understanding of living systems with molecular level resolution. Focus is on responsible conduct of research, rigor, and reproducibility in research. CSB 245. Graduate students in the department take courses in signal transduction networks, chemical biology, and other areas of importance to their research goals. CSB 290. Projects include: 1) Design and synthesis of novel chemical probes for serine and cysteine hydrolases. Engineered Substrate-Specific Delta PKC Antagonists to Enhance Cardiac Therapeutics. The Department of Chemical and Systems Biology is committed to providing advising to ensure graduate student personal, academic, and professional development. Current Research and Scholarly Interests Our lab applies biochemical and engineering principles to the development of protein-based tools for investigating biology in living animals. What is the purpose of the committee? 3 Units. CSB 242. Advanced Seminar in Microbial Molecular Biology. In collaboration with faculty, students also apply those principles to generate a potential research project, presented in both written and oral form. First-year students spend one quarter in each of three different laboratories, working closely with other graduate students, a professor, and postdoctoral fellows on various research projects. The Department of Chemical and Systems Biology is committed to providing academic advising in support of graduate student scholarly and professional development. Prerequisite: working knowledge of molecular biology, biochemistry and genetics, or instructor consent. By integrating genetic technologies, biochemical and chemical tools, quantitative measurements, and computational modeling, we strive to deconstruct these complex biological systems, predict emergent behaviors, and translate these discoveries into new medical therapies. When a student is in their fifth year, the committee meetings should be held twice a year. Open to all CSB students. Michael Lin Associate Professor of Neurobiology, of Bioengineering and, by courtesy, of Chemical and Systems Biology. Who else might a student consult for help or guidance, e.g., department chair, DGS, student services staff. 3 Units. Yuan-Chi Huang Postdoctoral Research Fellow, Chemical and Systems Biology. For information on how Chemical Engineering degree requirements have been affected by the pandemic, see the "COVID-19 Policies tab" in the "Chemical Engineering" of this bulletin.For University-wide policy changes related to the pandemic, see the "COVID-19 and Academic Continuity" section of this bulletin. Concepts and Applications in Chemical Biology. Explores the common principles controlling cell differentiation from stem cells to terminally differentiated cells. Maximum units are available by taking an additional contact hour. The molecular mechanisms through which cells receive and respond to external signals. Curricular Practical Training. The degree also requires a written thesis based on literature or laboratory research. Students undertake investigations sponsored by individual faculty members. California Chemical and Systems Biology Bootcamp. Tool development for genome engineering; Gene regulatory network of cell fate decisions; Cancer immunotherapy. The main focus of the program is cell signaling, chemical biology, and systems biology. Fellows join the Chemical and Systems Biology Postdoctoral Program through individual laboratories, and interested applicants should contact faculty members directly. Please contact Student Services with any questions regarding the course administration. Students and postdocs discuss scientific ethics and best practices for experimental design and interpretation. http://biosciences.stanford.edu/. 1 Unit. CSB 221. The HTBC is a shared resource (Bioscience Screening Facility) for the Stanford Cancer Institute. As mentioned above, committee meetings are held once a year after the qualifying exam. Search Stanford Bio-X affiliated faculty Molecular Dynamics, Systems Chemistry and Systems Biology. Join us! Students may opt for a fourth lab rotation and select an advisor in the Summer Quarter before their second year. Copyright Complaints Each meeting should include a time plan to ensure that the thesis project can be completed within five-and-a-half years. TBX16 Regulates Hox Gene Activation In Mesodermal Progenitor Cells. The systems work well in cultured mammalian cells, a variety of model organisms (e.g., flies, worms, frogs) and in living mice and rats. science. A Practical Guide to Drug Development in Academia: the SPARK Approach. The department participates in the four quarter Health and Human Disease and Practice of Medicine sequence which provides medical students with a comprehensive, systems-based education in physiology, pathology, microbiology, and pharmacology. Emphasis is on principles of cell signaling, the systems-level properties of signal transduction modules, and experimental strategies through which cell signaling pathways are being studied. As mentioned above, at the end of each quarter, first-. 2 Units. The limited size of the labs in the department allows for close tutorial contact between students, postdoctoral fellows, and faculty. Analysis of classic and current primary literature. At the beginning of each meeting, the student exits the room to allow for a discussion between the advisor and the rest of the committee. Genetic interaction mapping in mammalian cells using CRISPR interference. Principles of Cell Cycle Control. Close tutorial contact between students and faculty is stressed throughout the program. T-Plastin reinforces membrane protrusions to bridge matrix gaps during cell migration. Finally, the course allows the opportunity to learn from, and connect with leaders from companies within the Biotchnology sector. Students may reach out to any of these parties by email to set up a meeting and/or stop by the student services office. Quantitative Principles in Cell Differentiation. What is the process by which students can change advisors and when should this happen? Prerequisites: organic chemistry and biochemistry, or consent of instructor. Our laboratories emphasize interdisciplinary research that spans the biomedical sciences, including signal transduction, cell cycle regulation, chromatin remodeling, protein homeostasis, metabolism, and cell differentiation. Temporary Mailing Address: Biosciences PhD Admissions, 3165 Porter Drive. Henry Dreyfus Professor in Chemistry and Professor, by courtesy, of Chemical and Systems Biology Research and Scholarship Research in the Du Bois laboratory spans reaction methods development, natural product synthesis, and chemical biology, and draws on expertise in molecular design, molecular recognition, and physical organic chemistry. How does the department or program, advisor, and student decide when a student is ready to graduate? CSB 272. The main focus of the program is cell signaling, chemical biology, and systems biology. A method to rapidly create protein aggregates in living cells. Phone: 650.723.9785, © Stanford University, Stanford, California 94305. (Continuation of 240A) Advancing a drug from discovery of a therapeutic target to human trials and commercialization. This summary should be discussed with the advisor and sent to the committee members within one week for comment. Enrollment is limited to students with approved projects. The purpose of the committee is to further discuss the student’s thesis and provide feedback. CCSR 4145 Following the committee meeting, the student is required to summarize the discussion and formulate a revised plan for subsequent work. Graduate students select a thesis advisor generally at the end of Spring Quarter of their first year. Economics of Biotechnology. CSB 261. CSB 199. PhD in Chemical and Systems Biology (Stanford University) Email: onn@stanford.edu Phone: (650) 725-8986 Office: Beckman Center, Room B403A. When a student is in their fifth year, the committee meetings should be held twice a year. Focus on tractable model organisms; growth control; irreversible biochemical switches; chromosome duplication; mitosis; DNA damage checkpoints; MAPK pathway-cell cycle interface; oncogenesis. How are advisors initially assigned to or selected by incoming graduate students? CSB faculty Dr. Daniel Jarosz and graduate student Zachary Harvey featured in Stanford Medicine SCOPE. Rami N Hannoush Adjunct Professor, Chemical and Systems Biology Operations. This office provides information on educational programs, fellowship opportunities, career planning services, and health benefits. Students will learn about the process of drug discovery and development from target discovery, through drug optimization, preclinical testing, clinical testing, and commercialization. year students meet with the CSB Advisory Committee to discuss potential issues with the program, issues with host laboratories, classes, the qualifying exam, and career planning. Program. Invited lecturers participate as well. Jauch Professor and Professor of Chemical and Systems Biology, of Developmental Biology and of Chemistry James Chen He joined the Stanford faculty in 2003, and his research interests span organic chemistry, chemical biology, developmental biology, and cancer biology. 3 Units. Maximum units are available by taking an additional contact hour. How does meeting frequency change as the student progresses? 8 Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. Stanford University Department of Chemistry Center for Molecular Analysis and Design (CMAD) ChEM-H: Chemistry, Engineering & Medicine for Human Health NSF Center for Selective C–H Functionalization (CCHF) Chemical and Systems Biology (CSB) Both the advisor and advisee are key players in sustaining a collaborative relationship with integrity and professionalism. Students discuss readings focused on chemical and systems biology assigned by corresponding faculty host. Teruel Lab of the Department of Chemical & Systems Biology at Stanford School of Medicine Courses offered by the Department of Chemical and Systems Biology are listed under the subject code CSB on the Stanford Bulletin's ExploreCourses web site. 94305. The topics that are discussed include ideas about student activities as well as additions or changes to the program. Professor of Bioengineering and, by courtesy, of Chemical and Systems Biology. This technique allows rapid and reversible elimination of a specific protein in a variety of biological contexts. As mentioned above, at the end of each quarter, first-year students meet with the CSB Advisory Committee to discuss potential issues with the program, issues with host laboratories, classes, the qualifying exam, and career planning. The Department of Chemical and Systems Biology offers interdisciplinary training to prepare students for independent careers in biomedical science. How frequently should students meet with their advisors and how are those meetings set up? Stanford, The department is located in the Beckman Center for Molecular and Genetic Medicine within the Stanford University Medical Center. Professor of Pathology and of Microbiology and Immunology and, by courtesy, of Chemical and Systems Biology Current Research and Scholarly Interests Our lab uses chemical, biochemical, and cell biological methods to study protease function in human disease. SIM1 G3078A Chemical and Systems Biology. Biotechnology and Development of Therapeutics. Cell cycle regulation, especially M-phase regulation, in Xenopus embryos and mammalian cell lines; systems biology of signal transduction pathways. 3-4 Units. Chemical tools and techniques used to study and manipulate biological systems may be used to illustrate these principles. Courses offered by the Department of Chemical and Systems Biology are listed under the subject code CSB on the Stanford Bulletin's ExploreCourses web site. Explores the economic perspectives of various stakeholders--patients, providers, payers, biotechnology and pharmaceutical companies, FDA, and financial markets--and how they influence drug development. Committee meetings are held once a year after the qualifying exam. and Ph.D. degrees in Chemistry and Chemical Biology from Harvard, and he completed his postdoctoral studies at the Department of Molecular Biology and Genetics at Johns Hopkins. James became the Chair of Chemical and Systems Biology in 2016, and he is the Faculty Director of the Stanford High-Throughput Bioscience Center. The Department of Chemical and Systems Biology offers interdisciplinary training to prepare students for independent careers in biomedical science. The principles of organic and physical chemistry applied to biomolecules. Both the advisor and the advisee are expected to maintain professionalism and integrity. Current Research and Scholarly Interests Our laboratory combines chemistry and developmental biology to investigate the molecular events that regulate embryonic patterning, tissue regeneration, and tumorigenesis.