Avoid large amounts and use with caution. 2007;7:76-80. Statements made about products have not been evaluated by the Food and Drug Administration. Regardless of the myths and folktales surrounding red clover, one thing has been proven through time - the herb makes a powerful addition to your natural medicine arsenal. Le Bail JC, Champavier Y, Chulia AJ, Habrioux G. Effects of phytoestrogens on aromatase, 3beta and 17beta-hydroxysteroid dehydrogenase activities and human breast cancer cells. It also inhibited proliferation of human osteosarcoma U2SO cells by decreasing expression of miR-375 and Bcl-2, an apoptotic repressor, while increasing Bax, a pro-apoptotic protein (27). Phytomedicine. Clinical relevance has yet to be determined.Methotrexate: Red clover was reported to cause toxicity, resulting in severe vomiting and epigastric pain, when used along with methotrexate injections (19). Effects of phytoestrogens on aromatase, 3beta and 17beta-hydroxysteroid dehydrogenase activities and human breast cancer cells. The folk healers of Russia used Red clover to treat asthma. Red Clover Benefits: as a Phytoestrogen. 7. Red clover contains substances called isoflavones. The red clover (Trifolium pratense) isoflavone biochanin A inhibits aromatase activity and expression. Neuroprotective mechanisms of red clover and soy isoflavones in Parkinson's disease models View ORCID Profile Aurelie de Rus Jacquet , Abeje Ambaw , View ORCID Profile Mitali A Tambe , Michael Timmers , Sin Ying Ma , Qing-Li Wu , James E Simon , George P McCabe , Mary Ann Lila , Riyi Shi , View ORCID Profile Jean-Christophe Rochet 3. van de Weijer PH, Barentsen R. Isoflavones from red clover (Promensil) significantly reduce menopausal hot flush symptoms compared with placebo. Whilst there have been some very preliminary scientific studies to support the anti-cancer properties of Red Clover the evidence throughout the ages, like virtually all of our herbal lore, has been gathered through experience and observation. Patients should consult with their physicians before taking red clover supplements. 4. Two: This is often used for children that have a persistent, bad cough. It’s used to make an herbal supplement that may have some immune-boosting and positive hormonal effects, especially for postmenopausal women. Red Clover Basics. Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women. One: The isoflavones that are contained in the herb may help raise HDL cholesterol (the good kind). Neurocrit Care. Recent findings from a preclinical study suggest that red clover may increase resistance of prostate cancer cells to high-dose radiation while inhibiting the growth of normal prostate cells. In using this website you agree that neither Memorial Sloan Kettering nor any other party is or will be liable or otherwise responsible for any decision made or any action taken or any action not taken due to your use of any information presented at this website. The June 2004 edition of Breast Cancer Research states that red clover does not cause any oestrogenic increase in breast density, while human and synthetic oestrogen does. Clinical data show that supplementation with red clover isoflavones improves menopausal symptoms compared with placebo (7) (8), but systematic reviews are mixed (9) (24) (10). The effects of phytoestrogen isoflavones on bone density in women: a double-blind, randomized, placebo-controlled trial. No one with a hormone sensitive condition such as uterine cancer, breast cancer, ovarian cancer, uterine fibroids, or endometriosis, should use red clover. 2010;76:896-904. Isoflavones have generated considerable interest in the last decade because of their possible cancer-preventive, cardioprotective. Red clover: Red clover has been hailed as "the" herb for cancer by many herbalists. The relation between red clover and cancer is not been fully discovered yet.