It’s not uncommon for us to feel aches and pains in our muscles. Am J Med 87 (1989): s44-6, 30. Galatti L, Polimeni G, Salvo F, Romani M, Sessa A, Spina E "Short-term memory loss associated with rosuvastatin." 57. Postgrad Med J 83 (2007): 152-3, 25. Bronchitis 3. Peces R, Pobes A "Rhabdomyolysis associated with concurrent use of simvastatin and diltiazem." Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Vanpuijenbroek EP, Dubufvereijken PWG, Spooren PFMJ, Vandoormaal JJ "Possible increased risk of rhabdomyolysis during concomitant use of simvastatin and gemfibrozil." Br J Rheumatol 32 (1993): 647-8, 11. Very rarely, statins can cause life-threatening muscle damage called rhabdomyolysis (rab-doe-my-OL-ih-sis). © 2005 - 2019 WebMD LLC. Lancet 344 (1994): 1383-9, 52. Diarrhea 6. Arch Intern Med 152 (1992): 1093, 55. You may report them to the FDA. Are Statin Side Effects 'All in Your Head'? Side … Nakad A, Bataille L, Hamoir V, Sempoux C, Horsmans Y "Atorvastatin-induced acute hepatitis with absence of cross-toxicity with simvastatin." muscular pain, tenderness, wasting, or weakness, Blistering, peeling, or loosening of the skin, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, pains in the stomach, side, or abdomen, possibly radiating to the back, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, red skin lesions, often with a purple center, sores, ulcers, or white spots in the mouth or on the lips, weakness in the arms, hands, legs, or feet, excess air or gas in the stomach or intestines, feeling of constant movement of self or surroundings, pain or tenderness around the eyes and cheekbones, loss in sexual ability, desire, drive, or performance. Zocor (simvastatin)." The risk of very serious side effects is extremely low, and calculated in … Statins Side Effect #1: Muscle Pain. “My daughter was prescribed 40 mg of simvastatin. [Ref], Frequency not reported: Elevations in creatine kinase, myopathy, dermatomyositis, arthralgia, tendon rupture, Postmarketing reports: Muscle cramps, myalgia, rhabdomyolysis[Ref], This drug causes dose-related myopathy which, in rare cases maybe severe and sometimes take the form of rhabdomyolysis with or without renal failure secondary to myoglobinuria; rarely fatalities have occurred. Omar MA, Wilson JP "FDA adverse event reports on statin-associated rhabdomyolysis." An Infection 4. A meta-analysis of large randomized clinical trials." "Summaries for patients. Ann Pharmacother 30 (1996): 192, 3. J Cardiovasc Pharmacol 40 (2002): 163-71, 15. Medically reviewed by Drugs.com. Applies to simvastatin: oral suspension, oral tablet. JAMA 283 (2000): 3205-10, 14. ([2006 Dec]): 41. The more common side effects that can occur with simvastatin include: Indigestion 11. Stomach Cramps CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. These side effects may go away during treatment as your body adjusts to the medicine. Rudski L, Rabinovitch MA, Danoff D "Systemic immune reactions to HMG-CoA reductase inhibitors - Report of 4 cases and review of the literature." Head Pain 9. Arch Intern Med 161 (2001): 1456-7, 33. Morales K, Wittink M, Datto C, et al. Neurology 58 (2002): 1333-7, 48. "Simvastatin causes changes in affective processes in elderly volunteers." Medicine 77 (1998): 378-83, 56. If experienced, these tend to have a Severe expression, If experienced, these tend to have a Less Severe expression. Mauro VF, MacDonald JL "Simvastatin: a review of its pharmacology and clinical use." When she stopped taking it, the muscle pain would end. Cardiology 77 (1990): 58-65, 7. Nephron 89 (2001): 117-8, 37. Itakura H, Vaughn D, Haller DG, O'Dwyer PJ "Rhabdomyolysis from cytochrome p-450 interaction of ketoconazole and simvastatin in prostate cancer." Finsterer J, Zuntner G "Rhabdomyolysis from Simvastatin triggered by infection and muscle exertion." Newman TB, Hulley SB "Carcinogenicity of lipid-lowering drugs." Pharmacotherapy 25 (2005): 228-43, 28. Ann Pharmacother 36 (2002): 288-95, 24. Postgrad Med J 80 (2004): 551-2, 43. Katznelson S "Effect of HMG-CoA reductase inhibitors on chronic allograft rejection." Rhabdomyolysis can cause severe muscle pain, liver damage, kidney failure and death.

what are the most common side effects of simvastatin

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